(022) Men with History of Depression Are More Likely to Continue Use of Antidepressants If Erectile Dysfunction is Treated with Testosterone or Phosphodiesterase-5 Inhibitors

Abstract Introduction Erectile dysfunction (ED) affects an estimated 30 million men in the United States with 82% of erectile experiencing depressive symptoms. Prior literature has shown that initiation therapy for ED is associated a decrease symptoms; however, rates antidepressant continuation following not been analyzed. Objective Our goal was to analyze rate depression after prescribing testosterone or PDE-5 inhibitors dysfunction. Methods We queried TriNetX Diamond network database, health research including 212 patients, healthcare encounters, insurance claims data, and prescription data between 2009-2021. identified diagnosis (ICD-10: F32-33), 12 consecutive prior months prescriptions (VA Formulary: CN609), N52). then compared antidepressants over year who were prescribed PDE5i their versus had never The two cohorts matched on age, race, ethnicity. Rates discontinuation risk ratios (RR) 95% confidence interval (95% CI). Results 31,306 inhibitor without equal number weren't nor PDE5i. found 54% receiving continued using months; while, 49% (RR: 1.11, CI: 1.10-1.13). 4,468 patients prescriptions. 61% use subsequent while 1.24, 1.20-1.29). Conclusions conclude more likely continue usage 1 despite potential negative sexual side effects they may cause. patient's psychiatric conditions comorbidities should be considered when medications wellbeing order holistically treat patients. Disclosure No